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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Protein Z</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">Protein Z
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<p>Vorhandene Strukturdaten: 1LP1
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
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<td colspan="2" style="text-align:center;">360 Aminosäuren
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<td><a href="Koenzym" class="mw-redirect" title="Koenzym">Kofaktor</a>
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<td colspan="2" style="text-align:center;">Vitamin K
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Name</a>
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<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=9460">PROZ</a></i>
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<td>Externe IDs
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<ul><li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/176895">176895</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P22891">P22891</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P22891">Hovergen</a>
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<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>
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<td colspan="2" style="text-align:center;"><a href="Lebewesen" title="Lebewesen">Lebewesen</a>
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</p><p><b>Protein Z</b> ist ein <a href="Vitamin_K" title="Vitamin K">Vitamin-K</a>-abhängiges <a href="Glykoprotein" class="mw-redirect" title="Glykoprotein">Glykoprotein</a> im <a href="Blutplasma" title="Blutplasma">Blutplasma</a>, welches in der <a href="Leber" title="Leber">Leber</a> gebildet wird und an der <a href="H%C3%A4mostase" title="Hämostase">Blutgerinnung</a> beteiligt ist.
</p><p>Protein Z hat eine <a href="Molare_Masse" title="Molare Masse">molare Masse</a> von 62 kDa und besteht aus 360 <a href="Aminos%C3%A4uren" title="Aminosäuren">Aminosäuren</a>. Es wurde 1977 zunächst bei Rindern<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>, 1984 beim Menschen nachgewiesen<sup id="cite_ref-broze_2-0" class="reference"><a href="#cite_note-broze-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>. Protein Z ist an der Gerinnung beteiligt, indem es eine Anlagerung von <a href="Thrombin" title="Thrombin">Thrombin</a> an <a href="Endothel" title="Endothel">endotheliale</a> Phospholipidoberflächen unterstützt und mit Hilfe eines spezifischen Protease-Inhibitors die prokoagulatorische Aktivität des <a href="Faktor_X" class="mw-redirect" title="Faktor X">Faktors Xa</a> hemmt.<sup id="cite_ref-ains_3-0" class="reference"><a href="#cite_note-ains-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Protein Z hat dabei aber selbst keine <a href="Katalyse" title="Katalyse">katalytische</a> Funktion.<sup id="cite_ref-pone_4-0" class="reference"><a href="#cite_note-pone-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
</p><p>Ein verminderter Spiegel von Protein Z wird mit <a href="Thrombose" title="Thrombose">Thrombosen</a><sup id="cite_ref-sofi_5-0" class="reference"><a href="#cite_note-sofi-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> sowie mit <a href="Fehlgeburt" title="Fehlgeburt">Fehlgeburten</a> in Verbindung gebracht.<sup id="cite_ref-hoppe_6-0" class="reference"><a href="#cite_note-hoppe-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">C. V. Prowse, M. P. Esnouf: <cite style="font-style:italic">The isolation of a new warfarin-sensitive protein from bovine plasma</cite>. In: <cite style="font-style:italic"><a href="Biochem._Soc._Trans." class="mw-redirect" title="Biochem. Soc. Trans.">Biochem. Soc. Trans.</a></cite> 5. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 1977, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>255–256</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/892175?dopt=Abstract">PMID 892175</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Protein+Z&rft.atitle=The+isolation+of+a+new+warfarin-sensitive+protein+from+bovine+plasma&rft.au=C.+V.+Prowse%2C+M.+P.+Esnouf&rft.date=1977&rft.genre=journal&rft.issue=1&rft.jtitle=Biochem.+Soc.+Trans.&rft.pages=255-256&rft.pmid=892175&rft.volume=5.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-broze-2"><span class="mw-cite-backlink"><a href="#cite_ref-broze_2-0">↑</a></span> <span class="reference-text">
G. J. Broze, J. P. Miletich: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Human Protein Z</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Journal_of_Clinical_Investigation" title="Journal of Clinical Investigation">Journal of Clinical Investigation</a></cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>73</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, 1. April 1984, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>933–938</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1172/JCI111317">10.1172/JCI111317</a></span> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Protein+Z&rft.atitle=Human+Protein+Z&rft.au=G.+J.+Broze%2C+J.+P.+Miletich&rft.date=1984-04-01&rft.doi=10.1172%2FJCI111317&rft.genre=journal&rft.issue=4&rft.jtitle=Journal+of+Clinical+Investigation&rft.pages=933-938&rft.volume=73" style="display:none"> </span></span>
</li>
<li id="cite_note-ains-3"><span class="mw-cite-backlink"><a href="#cite_ref-ains_3-0">↑</a></span> <span class="reference-text">
J. Barth, K. Röhl, D. Jäger: <cite style="font-style:italic">Protein-Z-Mangel als seltene Ursache unklarer perioperativer Blutungen</cite>. In: <cite style="font-style:italic"><a href="AINS_%E2%80%93_An%C3%A4sthesiologie%2C_Intensivmedizin%2C_Notfallmedizin%2C_Schmerztherapie" title="AINS – Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie">AINS</a></cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>38</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>9</span>, September 2003, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>605–608</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1055/s-2003-41858">10.1055/s-2003-41858</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Protein+Z&rft.atitle=Protein-Z-Mangel+als+seltene+Ursache+unklarer+perioperativer+Blutungen&rft.au=J.+Barth%2C+K.+R%C3%B6hl%2C+D.+J%C3%A4ger&rft.date=2003-09&rft.doi=10.1055%2Fs-2003-41858&rft.genre=journal&rft.issue=9&rft.jtitle=AINS&rft.pages=605-608&rft.volume=38" style="display:none"> </span></span>
</li>
<li id="cite_note-pone-4"><span class="mw-cite-backlink"><a href="#cite_ref-pone_4-0">↑</a></span> <span class="reference-text">
Antje Butschkau, Nana-Maria Wagner, Berit Genz, Brigitte Vollmar, Ingo Ahrens: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Protein Z Exerts Pro-Angiogenic Effects and Upregulates CXCR4</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="PLoS_ONE" class="mw-redirect" title="PLoS ONE">PLoS ONE</a></cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>9</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>12</span>, 4. Dezember 2014, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>e113554</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1371/journal.pone.0113554">10.1371/journal.pone.0113554</a></span> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Protein+Z&rft.atitle=Protein+Z+Exerts+Pro-Angiogenic+Effects+and+Upregulates+CXCR4&rft.au=Antje+Butschkau%2C+Nana-Maria+Wagner%2C+Berit+Genz%2C+...&rft.date=2014-12-04&rft.doi=10.1371%2Fjournal.pone.0113554&rft.genre=journal&rft.issue=12&rft.jtitle=PLoS+ONE&rft.pages=e113554&rft.volume=9" style="display:none"> </span></span>
</li>
<li id="cite_note-sofi-5"><span class="mw-cite-backlink"><a href="#cite_ref-sofi_5-0">↑</a></span> <span class="reference-text">
F. Sofi, F. Cesari, R. Abbate, G. F. Gensini, G. J. Broze, S. Fedi: <cite class="lang" lang="en" dir="auto" style="font-style:italic">A meta-analysis of potential risks of low levels of protein Z for diseases related to vascular thrombosis</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Thrombosis_and_Haemostasis" title="Thrombosis and Haemostasis">Thrombosis and Haemostasis</a></cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>103</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, 2010, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>749–756</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1160/TH09-09-0645">10.1160/TH09-09-0645</a></span> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Protein+Z&rft.atitle=A+meta-analysis+of+potential+risks+of+low+levels+of+protein+Z+for+diseases+related+to+vascular+thrombosis&rft.au=F.+Sofi%2C+F.+Cesari%2C+R.+Abbate%2C+...&rft.date=2010&rft.doi=10.1160%2FTH09-09-0645&rft.genre=journal&rft.issue=4&rft.jtitle=Thrombosis+and+Haemostasis&rft.pages=749-756&rft.volume=103" style="display:none"> </span></span>
</li>
<li id="cite_note-hoppe-6"><span class="mw-cite-backlink"><a href="#cite_ref-hoppe_6-0">↑</a></span> <span class="reference-text">
B. Hoppe, A. Salama, H. Kiesewetter, Th. Dörner: <cite style="font-style:italic">Protein-Z-Spiegel und Protein-Z-Antikörper bei Abortneigung: aktuelle Perspektiven</cite>. In: <cite style="font-style:italic">Vascular Care</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>7</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>32</span>, Februar 2004 (<a rel="nofollow" class="external text" href="http://vascularcare.de/vascularcare/wp-content/uploads/2010/10/Hoppe_Protein_Z_VC2_2004.pdf">vascularcare.de</a> [PDF]).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Protein+Z&rft.atitle=Protein-Z-Spiegel+und+Protein-Z-Antik%C3%B6rper+bei+Abortneigung%3A+aktuelle+Perspektiven&rft.au=B.+Hoppe%2C+A.+Salama%2C+H.+Kiesewetter%2C+...&rft.date=2004-02&rft.genre=journal&rft.issue=32&rft.jtitle=Vascular+Care&rft.volume=7" style="display:none"> </span></span>
</li>
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